Assessment of Therapeutic Potential and Phytochemical Profiling in Different Solvent Extracts of Centella asiatica
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Type
Article
Date
2023
Journal Title
NBU Journal of Plant Sciences
Journal Editor
Chowdhury, Monoranjan
Journal ISSN
Volume Title
Publisher
University of North Bengal
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Saran Kumar Gupta. (2023). Assessment of Therapeutic Potential and Phytochemical Profiling in Different Solvent Extracts of Centella asiatica. NBU Journal of Plant Sciences, 15, 79–86. https://doi.org/10.55734/nbujps.2023.v15i01.012
Authors
Saran Kumar Gupta
Advisor
Editor
Abstract
Centella asiatica (L.) Urban, commonly known as Indian pennywort, a small perennial herb from the Apiaceae family has been used in traditional medicine for thousands of years. This study aimed to evaluate the effect of different extraction solvents on the therapeutic and phytochemical profiles of various parts of Centella asiatica. Among the various plant parts assessed, the leaves exhibited the best antioxidant and in vitro antidiabetic activity and the highest amount of phytoconstituents compared to petiole and root. Methanol was identified as the most effective solvent, yielding optimal IC50 values for DPPH (30.65 μg/ml) and ABTS (45.23 μg/ml). Additionally, the methanolic extract of leaves exhibited highest content of phenolics (65.49 mg GAE/g DW) and flavonoids (12.56 mg QE/g DW). The methanolic leaf extract also demonstrated a promising inhibition potential against α-amylase and α-glucosidase enzymes and possessed elevated levels of alkaloids, glycosides, tannins and terpenoids. This study demonstrated significant variations in the therapeutic potential of Centella asiatica, attributed to differences in the nature of the extraction solvents.
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Article info
Received 05 September 2023
Revised 24 January 2024
Accepted 25 February 2024
Citation
Accession No
Call No
Book Title
Edition
Volume
ISBN No
Volume Number
15
Issue Number
ISSN No
0974-6927
eISSN No
Pages
Pages
79 - 86