University Publications

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Open Access
Investigation of codon and amino-acid usages in a Rhizobium phage
(University of North Bengal, 2009-03) Sur, S; Bajwa, B; Bajwa, M; Basistha, B; Bothra, AK; Sen, A
In this study codon and amino-acid usage of the phage genes were analyzed to understand the functionality of the protein coding genes. Low bias was noticed. The genes were influenced by mutational bias. Reasonable number of optimal codons was noticed. GC3 content does not play any role in synonymous codon usage: however gene expression levels and hydropathicity determine codon and amino acid usage variation. Highly expressed genes play an important role in infectivity.
Open Access
Molecular modelling of a pathogenesis related protein from Solanum tuberosum
(University of North Bengal, 2009-03) Thakur, S; Sur, S; Bose, D; Goyal, AK; Mishra, T; Rai, R; Bhattacharya, M; Bothra, AK; Sen, A
The pathogenesis related proteins are an important group of proteins produced in plants in response to infection by phytopathogens. The PR protein of Solanum tuberosum form an integral part of the host defence system. The unavailability of the crystal structure of the PR protein of Solanum tuberosum prompted us to undertake molecular modeling technique to look into the active sites and infer upon the structure function relationship. The model was built using I CFE as template. The functionality was studied. The model offers a reliable base to start X-crystallography and NMR based studies.