Explorative studies towards the synthesis of biocogically active carbocyclic and heterocyclic systems
DOI
Access Status
This content is available to Open Access.
To download content simply use the links provided under the Files section.
More information about licence and terms of use for this content is available in the Rights section.
Type
Thesis
Date
2023
Journal Title
Journal Editor
Journal ISSN
Volume Title
Publisher
University of North Bengal
Statistics
Total views and downloads
Views
2Downloads
3Citation
Kundu Tandra. (2023). Explorative studies towards the synthesis of biocogically active carbocyclic and heterocyclic systems [Doctoral thesis, University of North Bengal]. https://ir.nbu.ac.in/handle/123456789/5359
Authors
Advisor
Editor
Abstract
Beginning from the summer days of 2018, it took nearly five long years for me to finish the
research work incorporated in this thesis entitled “EXPLORATIVE STUDIES TOWARDS
THE SYNTHESIS OF BIOLOGICALLY ACTIVE CARBOCYCLIC AND
HETEROCYCLIC SYSTEMS”. The work is mainly focused on development of efficient
and environment benign methodologies for the synthesis of carbocyclic and heterocyclic
compounds. The entire work depicted in this thesis has been divided into five chapters.
In the beginning, Chapter I deals with a brief review on the development of novel reaction
protocols for the transformation reaction on carbocyclic and heterocyclic compounds. These
compounds have extensively been used in the designing of various pharmaceutically
significant compounds. Apart from this, they are considered to be powerful building blocks
for the construction of biologically active compounds.
In Chapter II bio-based, environmental benign media ethyl lactate was used in synthesis of
verities of unsymmetrical azobenzenes. The methodology proceeds without the use of toxic
transition metal catalyst and avoids harsh reaction conditions. A green methodology is thus
reported with synthesis of good yield of the product.
In Chapter III a very simple, efficient and environment benign protocol for the synthesis of
diverse array of 2,3-dihydroquinazolin-4(1H)-ones using wide range of aldehydes, isatoic
anhydride with ammonium acetate was described. Eucalyptol, a bio-degradable solvent was
used in this methodology which itself acted as a catalyst thus avoiding the use of toxic metals
or hazardous materials. The activity of this bio-based reaction medium, eucalyptol was
further extended towards the synthesis of isoxazolone derivatives using wide range of
aldehydes, ethyl acetoacetate and hydroxyl amine hydrochloride.
In Chapter IV synthesis of 1-amidoalkyl-2-naphthol and 1-thioamidoalkyl-2-naphthol is
discussed. These derivatives carry great importance now a day as because they can easily be
transformed to biologically potent heterocyclic entities via hydrolysis of amidic groups. In
this chapter humic acid has been explored as catalyst with the association of operational
simplicity of the method, mild reaction conditions, shorter reaction time. By this process,
good yield of desired product 1-amidoalkyl-2-napthol is obtained by using aldehyde, β-
napthol and acetamide. And 1-thioamidoalkyl-2-napthol is also prepared by using aldehyde,
β-napthol and thioacetamide.
In Chapter V inexpensive, environmental benign catalyst boric acid was used in synthesis of
verities of bis-lawsones. The methodology proceeds without the use of toxic metal catalyst
and avoids harsh reaction conditions. A green methodology is thus reported with synthesis of
good yield of the product by reacting lawsone with wide range of aldehydes.
Description
Citation
Accession No
311166
Call No
TH 547.59:K95e
Book Title
Edition
Volume
ISBN No
Volume Number
Issue Number
ISSN No
eISSN No
Pages
xxiii,103p.