Acknowledgement _________________________________________________________________________ I would like to express deep gratitude towards my supervisor Dr. Bhaskar Chakraborty, Associate Professor in Chemistry and Head of department, Sikkim Government College, Gangtok who has been an integral part in shaping these four years in research into a unique and rewarding experience for me. Throughout the research work I have received expert criticism, valuable comment and above all his best loving care. His creativity has had a significant impact on my research, and his passion for his work has in turn provided me with a wealth of opportunities and for which I am truly grateful. I am also equally grateful to Dr. Pranab Ghosh, Associate Professor in Chemistry, University of North Bengal for guiding me with his advices. I have also had the good fortune to interact with faculty members at both Department of Chemistry, University of North Bengal and Indian Association for the Cultivation of Science, Jadavpur over the course of my PhD career. Heartfelt thanks goes to Prof. B. Basu and Dr. A.K Nanda, Department of Chemistry, University of North Bengal for their constructive ideas and for providing NMR spectra of some of the vital compounds related to my present work. I would also take this opportunity to thank Prof. B. C. Ranu and Prof. A. Dey of Indian Association for the Cultivation of Science, Jadavpur for their valuable suggestion relating to the research work. Thanks are also due to Dr. M. P. Kharel, Principal, Sikkim Government College, Tadong, Dr. S. K. Pradhan, former Principal, Sikkim Government College, Dr. C. B. Sunwar, former Principal, Sikkim Government College for their enthusiastic support, constant co-operation and for providing research facilities. I am equally grateful to scientist in-charge, SAIF, CDRI, Lucknow for providing IR, NMR, MS Spectral data. I express my personal appreciation of the assistance given by Dr.Manjit Singh Chhetri, Dr. Saurav Kafley, Shri Govinda Prasad Luitel, Chiran Devi Sharma, Neelam Rai and Esmita Chhetri, Department of Chemistry, Sikkim Government College in this work. I am equally thankful to Dr. Amalesh Samanta of Jadavpur University, Kolkata for helping in finding out the biological aspects of the entire work. Without their support my review work would not have been completed. I would like to express my thanks to Mr. Denlock Lepcha, Mr.Bijay Prakash Rai, Mr. Royal Karthak, Mr. Arun Thapa, staff members of Chemistry Department, Sikkim Government College for his continuous support. I would like to express my heartfelt thanks to Mrs. Malini Chakraborty for her continuous encouragement. Finally, I would like to express my deep gratitude towards my parents, family members and specially to my dear wife Yasoda. Their affection ever encouraged me for the entire work. Lastly, all the people who rendered valuable help and support in direct and indirect ways in bringing this research work to completion are sincerely acknowledged. ( Date : 21.06.2016) [PRAWIN KUMAR SHARMA] Department of Chemistry, Sikkim Government College , Gangtok ,Sikkim- 737102