A homology model of 16s rRNA tertiary structure of Frankia

Abstract

Tertiary structure determination of biomolecule is important for knowing their function. Although different experimental prediction methods are present computational approach has an important role. Frankia sp., is a nitrogen fixing bacterium promoting soil fertility.16S ribosomal nucleic acid molecule is not only important as a molecular signature for classification and identification of organisms but has a great impact on protein synthesis. Here we have developed 3D structure of 16S rRNA of three different strains of Frankia viz Frankia sp. strain HFPCc13, Frankia alni strain ACN14a and Frankia sp. strain EAN1pec through knowledge based coarsed to atomic approach. The occurrence of tertiary structural motifs like C- loop. E-loop. GNRA tetraloop, hook-turn, sarcin-ricin motif, K-turn, reverse K-turn were examined. The presence of such sort of motif stabilizes the complexed RNA structures through their Watson-Crick, Non- Watson Crick, tandem sheared stacking packages. Among them E-loop, K-turn, sarcin-ricin motif have significant functional importance for transporting the biomolecules, RNA-protein interaction, RNA-RNA interaction/RNA-drug interaction accordingly.